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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4H
All Species:
18.48
Human Site:
S144
Identified Species:
36.97
UniProt:
Q15056
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15056
NP_071496.1
248
27385
S144
G
M
G
S
S
R
E
S
R
G
G
W
D
S
R
Chimpanzee
Pan troglodytes
XP_001148962
248
27338
S144
G
M
G
S
S
R
E
S
R
G
G
W
D
S
R
Rhesus Macaque
Macaca mulatta
XP_001082007
248
27381
S144
G
M
G
S
S
R
E
S
R
G
G
W
D
S
R
Dog
Lupus familis
XP_849626
233
25675
S129
G
M
G
G
P
G
E
S
R
G
G
W
D
S
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9WUK2
248
27322
S144
G
M
G
G
S
R
E
S
R
G
G
W
D
S
R
Rat
Rattus norvegicus
Q5XI72
248
27306
P144
G
M
G
G
S
R
E
P
R
G
G
W
D
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001074330
146
16260
G54
L
P
F
N
T
V
Q
G
D
I
D
A
I
F
K
Frog
Xenopus laevis
P52299
153
17546
G61
H
E
L
F
S
K
S
G
D
V
K
R
I
V
M
Zebra Danio
Brachydanio rerio
XP_002664590
262
27986
A164
D
Q
S
G
G
G
A
A
G
E
M
G
F
R
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3L6
154
17700
G62
D
V
R
V
I
V
M
G
L
D
K
Y
K
K
T
Honey Bee
Apis mellifera
XP_392894
274
29878
S158
G
Y
V
G
Q
G
Q
S
H
G
G
R
Q
G
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_788335
307
31424
R180
G
G
S
W
G
D
D
R
R
G
G
G
G
G
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.5
91.5
N.A.
98.7
97.9
N.A.
N.A.
54.8
22.1
72.5
N.A.
22.5
41.2
N.A.
43.3
Protein Similarity:
100
99.5
100
91.5
N.A.
99.1
98.7
N.A.
N.A.
57.6
31.4
78.6
N.A.
33.8
59.4
N.A.
53.7
P-Site Identity:
100
100
100
80
N.A.
93.3
86.6
N.A.
N.A.
0
6.6
0
N.A.
0
26.6
N.A.
33.3
P-Site Similarity:
100
100
100
80
N.A.
93.3
86.6
N.A.
N.A.
26.6
13.3
6.6
N.A.
13.3
33.3
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
9
9
0
0
0
9
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
17
0
0
0
0
9
9
0
17
9
9
0
50
0
9
% D
% Glu:
0
9
0
0
0
0
50
0
0
9
0
0
0
0
0
% E
% Phe:
0
0
9
9
0
0
0
0
0
0
0
0
9
9
0
% F
% Gly:
67
9
50
42
17
25
0
25
9
67
67
17
9
17
0
% G
% His:
9
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
9
0
0
0
0
9
0
0
17
0
0
% I
% Lys:
0
0
0
0
0
9
0
0
0
0
17
0
9
9
9
% K
% Leu:
9
0
9
0
0
0
0
0
9
0
0
0
0
0
0
% L
% Met:
0
50
0
0
0
0
9
0
0
0
9
0
0
0
9
% M
% Asn:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
0
0
9
0
0
9
0
0
0
0
0
0
0
% P
% Gln:
0
9
0
0
9
0
17
0
0
0
0
0
9
0
0
% Q
% Arg:
0
0
9
0
0
42
0
9
59
0
0
17
0
9
59
% R
% Ser:
0
0
17
25
50
0
9
50
0
0
0
0
0
50
9
% S
% Thr:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
9
% T
% Val:
0
9
9
9
0
17
0
0
0
9
0
0
0
9
0
% V
% Trp:
0
0
0
9
0
0
0
0
0
0
0
50
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
0
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _